ISSN 1662-4009 (online)

ey0016.14-11 | (1) | ESPEYB16

14.11. Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

M Fulde , F Sommer , B Chassaing , K van Vorst , A Dupont , M Hensel , M Basic , R Klopfleisch , P Rosenstiel , A Bleich , F Backhed , AT Gewirtz , MW Hornef

To read the full abstract: Nature 2018;560:489–493.This paper reports competitive gut colonization experiments in mice. Compared to adult mice, neonatal mice showed much higher expression of the flagellin receptor Tlr5 in their intestinal epithelial cells, and exposure to this protein during the first 2 weeks of life, before weaning, was crucial in determining lifelong...